Fast dependent components for fMRI analysis

  • Authors:
  • Eerika Savia;Arto Klami;Samuel Kaski

  • Affiliations:
  • Helsinki University of Technology, Department of Information and Computer Science, P.O. Box 5400, FI-02015 TKK, Finland;Helsinki University of Technology, Department of Information and Computer Science, P.O. Box 5400, FI-02015 TKK, Finland;Helsinki University of Technology, Department of Information and Computer Science, P.O. Box 5400, FI-02015 TKK, Finland

  • Venue:
  • ICASSP '09 Proceedings of the 2009 IEEE International Conference on Acoustics, Speech and Signal Processing
  • Year:
  • 2009

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Abstract

Canonical correlation analysis (CCA) can be used to find correlating projections of two datasets with co-occurring samples. Instead of correlation, we would typically want to find more general dependencies, measured by mutual information. Variants of CCA based on non-parametric estimation of mutual information have been proposed previously; they outperform traditional CCA for non-Gaussian data but require infeasible amounts of computation for already quite modest sample sizes. We introduce a novel variant that uses a semiparametric estimate leading to a considerably faster algorithm. We apply the method on searching for statistical dependencies between multi-sensory stimuli and functional magnetic resonance imaging (fMRI) of brain activity- in contrast to using regression on either of them.