Handbook of mathematics (3rd ed.)
Handbook of mathematics (3rd ed.)
What Can a Neuron Learn with Spike-Timing-Dependent Plasticity?
Neural Computation
Computing the Optimally Fitted Spike Train for a Synapse
Neural Computation
Biophysics of Computation: Information Processing in Single Neurons (Computational Neuroscience Series)
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When entering a synapse, presynaptic pulse trains are filtered according to the recent pulse history at the synapse and also with respect to their own pulse time course. Various behavioral models have tried to reproduce these complex filtering properties. In particular, the quantal model of neurotransmitter release has been shown to be highly selective for particular presynaptic pulse patterns. However, since the original, pulse-iterative quantal model does not lend itself to mathematical analysis, investigations have only been carried out via simulations. In contrast, we derive a comprehensive explicit expression for the quantal model. We show the correlation between the parameters of this explicit expression and the preferred spike train pattern of the synapse. In particular, our analysis of the transmission of modulated pulse trains across a dynamic synapse links the original parameters of the quantal model to the transmission efficacy of two major spiking regimes, that is, bursting and constant-rate ones.