The prediction of the degree of exposure to solvent of amino acid residues via genetic programming

  • Authors:
  • Simon Handley

  • Affiliations:
  • Stanford University, Stanford, CA

  • Venue:
  • GECCO '96 Proceedings of the 1st annual conference on Genetic and evolutionary computation
  • Year:
  • 1996

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Abstract

This paper applies a new extension to genetic programming (Handley 1996, this volume) to a problem on which genetic programming has previously been applied (Handley 1994). The problem is to predict the degree of exposure to solvent (the buriedness) of a protein's amino acid residues given only the protein's primary structure. The best programs evolved are better than the programs evolved in an earlier set of experiments that used a problem-specific ad-hoc function set (Handley 1994).