A Mutual Information Approach to Data Integration for Alzheimer's Disease Patients

  • Authors:
  • Italo Zoppis;Erica Gianazza;Clizia Chinello;Veronica Mainini;Carmen Galbusera;Carlo Ferrarese;Gloria Galimberti;Alessandro Sorbi;Barbara Borroni;Fulvio Magni;Giancarlo Mauri

  • Affiliations:
  • Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milano, Italy;Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy;Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy;Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy;Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy;Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, Monza (MI), Italy and Department of Neurology, San Gerardo Hospital, Monza (MI), Italy;Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, Monza (MI), Italy;Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy;Department of Neurology, University of Brescia, Center for Aging Brain and Dementia, Brescia, Italy;Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy;Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milano, Italy

  • Venue:
  • AIME '09 Proceedings of the 12th Conference on Artificial Intelligence in Medicine: Artificial Intelligence in Medicine
  • Year:
  • 2009

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Abstract

Clinical data alignment plays a critical role in identifying important features for significant experiments. A central problem is data fusion i.e., how to correctly integrate data provided by different labs. This integration is done in order to increase ability of inferring target classes of controls and patients. Our paper proposes an approach based both on a information theoretic perspective, generally used in a feature construction problem [3] and on the approximated solution for a mathematical programming task (i.e. the weighted bipartite matching problem [6]). Numerical evaluations with two competitive approaches show the improved performance of the proposed method. For this evaluation we used data sets from plasma / ethylenediaminetetraacetic acid (EDTA) of controls and Alzheimer patients collected in three different hospitals.