Computing minimal surfaces via level set curvature flow
Journal of Computational Physics
International Journal of Computer Vision
A Level-Set Approach to 3D Reconstruction from Range Data
International Journal of Computer Vision
A fast level set method for segmentation of low contrast noisy biomedical images
Pattern Recognition Letters
Fast Implicit Active Contour Models
Proceedings of the 24th DAGM Symposium on Pattern Recognition
A fast algorithm for level set-like active contours
Pattern Recognition Letters
A Fast Level Set-Like Algorithm with Topology Preserving Constraint
CAIP '09 Proceedings of the 13th International Conference on Computer Analysis of Images and Patterns
IEEE Transactions on Image Processing
A Real-Time Algorithm for the Approximation of Level-Set-Based Curve Evolution
IEEE Transactions on Image Processing
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An accurate localization of a cell nucleus boundary is inevitable for any further quantitative analysis of various subnuclear structures within the cell nucleus. In this paper, we present a novel approach to the cell nucleus segmentation in fluorescence microscope images exploiting the level set framework. The proposed method works in two phases. In the first phase, the image foreground is separated from the background using a fast level set-like algorithm by Nilsson and Heyden [1]. A binary mask of isolated cell nuclei as well as their clusters is obtained as a result of the first phase. A fast topology-preserving level set-like algorithm by Maška and Matula [2] is applied in the second phase to delineate individual cell nuclei within the clusters. The potential of the new method is demonstrated on images of DAPI-stained nuclei of a lung cancer cell line A549 and promyelocytic leukemia cell line HL60.