Multi-Agents System to Model Cell Signalling by Using Fuzzy Cognitive Maps. Application to Computer Simulation of Multiple Myeloma

Authors:
Vincent Rodin;Gabriel Querrec;Pascal Ballet;François-Régis Bataille;Gireg Desmeulles;Jean-François Abgrall;Jacques Tisseau
Affiliations:
-;-;-;-;-;-;-
Venue:
BIBE '09 Proceedings of the 2009 Ninth IEEE International Conference on Bioinformatics and Bioengineering
Year:
2009

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Abstract

In order to simulate biological processes, we use multi-agents system. However, modelling cell behavior in systems biology is complex and may be based on intracellular biochemical pathway. So, we have developed in this study a Fuzzy Influence Graph to model MAPK pathway. A Fuzzy Influence Graph is also called Fuzzy Cognitive Map.This model can be integrated in agents representing cells. Results indicate that despite individual variations, the average behavior of MAPK pathway in a cells group is close to results obtained by ordinary differential equations. So, we have also modelled multiple myeloma cells signalling by using this approach.