An Ontology to Integrate Transcriptomics and Interatomics Data Involved in Gene Pathways of Genome Stability

  • Authors:

  • Giovani Rubert Librelotto;José Carlos Mombach;Marialva Sinigaglia;Éder Simão;Heleno Borges Cabral;Mauro A. Castro

  • Affiliations:

  • UFSM --- Universidade Federal de Santa Maria., Santa Maria, Brasil 97105-900;UFSM --- Universidade Federal de Santa Maria., Santa Maria, Brasil 97105-900;UFRGS --- Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil;UFSM --- Universidade Federal de Santa Maria., Santa Maria, Brasil 97105-900;UNIFRA, Centro Universitário Franciscano, Santa Maria, Brasil 97010-032;UFRGS --- Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil

  • Venue:
  • BSB '09 Proceedings of the 4th Brazilian Symposium on Bioinformatics: Advances in Bioinformatics and Computational Biology
  • Year:
  • 2009

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Abstract

Disruption of the mechanisms that regulate cell-cycle checkpoints, DNA repair, and apoptosis results in genomic instability and the development of cancer. The description of the complex network of these pathways requires news tools to integrate large quantities of experimental data in the design of biological information systems. In this context we present Ontocancro an extensible ontology and an architecture designed to facilitate the integration of data originating from different public databases in a single- and well-documented relational database. Ontocancro is an Ontology stored in a knowledge database designed to be a source of information to integrate transcriptomics and interatomics data involved in gene pathways of Genome Maintenance Mechanisms (GMM).