Surface shape and curvature scales
Image and Vision Computing
Geometric Level Set Methods in Imaging,Vision,and Graphics
Geometric Level Set Methods in Imaging,Vision,and Graphics
Multivariate Density-Based 3D Shape Descriptors
SMI '07 Proceedings of the IEEE International Conference on Shape Modeling and Applications 2007
A methodology for analyzing curvature in the developing brain from preterm to adult
International Journal of Imaging Systems and Technology - Human Brain Imaging
MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention - Volume Part I
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part II
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part II
Brain morphometry by probabilistic latent semantic analysis
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part II
Tract-based probability densities of diffusivity measures in DT-MRI
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part I
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The paper presents a novel statistical framework for cortical folding pattern analysis that relies on a rich multivariate descriptor of folding patterns in a region of interest (ROI). The ROI-based approach avoids problems faced by spatial-normalization-based approaches stemming from the severe deficiency of homologous features between typical human cerebral cortices. Unlike typical ROI-based methods that summarize folding complexity or shape by a single number, the proposed descriptor unifies complexity and shape of the surface in a high-dimensional space. In this way, the proposed framework couples the reliability of ROI-based analysis with the richness of the novel cortical folding pattern descriptor. Furthermore, the descriptor can easily incorporate additional variables, e.g. cortical thickness. The paper proposes a novel application of a nonparametric permutation-based approach for statistical hypothesis testing for any multivariate high-dimensional descriptor. While the proposed framework has a rigorous theoretical underpinning, it is straightforward to implement. The framework is validated via simulated and clinical data. The paper is the first to quantitatively evaluate cortical folding in neonates with complex congenital heart disease.