Cortical Correspondence with Probabilistic Fiber Connectivity

  • Authors:
  • Ipek Oguz;Marc Niethammer;Josh Cates;Ross Whitaker;Thomas Fletcher;Clement Vachet;Martin Styner

  • Affiliations:
  • Departments of Computer Science,;Departments of Computer Science, and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill,;Scientific Computing and Imaging Institute, University of Utah, Salt Lake City,;Scientific Computing and Imaging Institute, University of Utah, Salt Lake City,;Scientific Computing and Imaging Institute, University of Utah, Salt Lake City,;Psychiatry,;Departments of Computer Science, and Psychiatry,

  • Venue:
  • IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
  • Year:
  • 2009

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Abstract

This paper presents a novel method of optimizing point-based correspondence among populations of human cortical surfaces by combining structural cues with probabilistic connectivity maps. The proposed method establishes a tradeoff between an even sampling of the cortical surfaces (a low surface entropy) and the similarity of corresponding points across the population (a low ensemble entropy). The similarity metric, however, isn't constrained to be just spatial proximity, but uses local sulcal depth measurements as well as probabilistic connectivity maps, computed from DWI scans via a stochastic tractography algorithm, to enhance the correspondence definition. We propose a novel method for projecting this fiber connectivity information on the cortical surface, using a surface evolution technique. Our cortical correspondence method does not require a spherical parameterization. Experimental results are presented, showing improved correspondence quality demonstrated by a cortical thickness analysis, as compared to correspondence methods using spatial metrics as the sole correspondence criterion.