Using UML to Model EAE and Its Regulatory Network

Authors:
Mark Read;Jon Timmis;Paul S. Andrews;Vipin Kumar
Affiliations:
Department of Computer Science, University of York, UK;Department of Computer Science, University of York, UK and Department of Electronics, University of York, UK;Department of Computer Science, University of York, UK;Laboratory of Autoimmunity, Torrey Pines Institute for Molecular Studies,
Venue:
ICARIS '09 Proceedings of the 8th International Conference on Artificial Immune Systems
Year:
2009

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Abstract

Experimental Autoimmune Encephalomyelitis (EAE) is an autoimmune disease in mice which serves as a model for multiple sclerosis in humans [4,5]. The disease constitutes the direction of immunity towards myelin, an insulatory material that covers neurons. The consequential damage to the central nervous system (CNS) can lead to paralysis and death [6].