Motif discovery by monotone scores
Discrete Applied Mathematics
Assessing the significance of sets of words
CPM'05 Proceedings of the 16th annual conference on Combinatorial Pattern Matching
Faster variance computation for patterns with gaps
MedAlg'12 Proceedings of the First Mediterranean conference on Design and Analysis of Algorithms
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We study a problem related to the extraction of over-represented words from a given source text x , of length n . The words are allowed to occur with k mismatches, and x is produced by a source over an alphabet Σ according to a Markov chain of order p . We propose an online algorithm to compute the expected number of occurrences of a word y of length m in O (mk |Σ| p + 1). We also propose an offline algorithm to compute the probability of any word that occurs in the text in O (k |Σ|2) after O (nk |Σ| p + 1) pre-processing. This algorithm allows us to compute the expectation for all the words in a text of length n in O (kn 2|Σ|2 + nk |Σ| p + 1), rather than in O (n 3 |Σ| p + 1) that can be obtained with other methods. Although this study was motivated by the motif discovery problem in bioinformatics, the results find their applications in any other domain involving combinatorics on words.