Mental models: towards a cognitive science of language, inference, and consciousness
Mental models: towards a cognitive science of language, inference, and consciousness
Formal ontology, conceptual analysis and knowledge representation
International Journal of Human-Computer Studies - Special issue: the role of formal ontology in the information technology
Toward principles for the design of ontologies used for knowledge sharing
International Journal of Human-Computer Studies - Special issue: the role of formal ontology in the information technology
Knowledge engineering: principles and methods
Data & Knowledge Engineering - Special jubilee issue: DKE 25
Organizational knowledge resources
Decision Support Systems - Knowledge management support of decision making
Data integration: a theoretical perspective
Proceedings of the twenty-first ACM SIGMOD-SIGACT-SIGART symposium on Principles of database systems
Social Science, Technical Systems and Cooperative Work: The Great Divide
Social Science, Technical Systems and Cooperative Work: The Great Divide
Working Knowledge: How Organizations Manage What They Know
Working Knowledge: How Organizations Manage What They Know
Bottom-Up Construction of Ontologies
IEEE Transactions on Knowledge and Data Engineering
What Are Ontologies, and Why Do We Need Them?
IEEE Intelligent Systems
Better Knowledge Management through Knowledge Engineering
IEEE Intelligent Systems
PostgreSQL
The description logic handbook: theory, implementation, and applications
The description logic handbook: theory, implementation, and applications
Ontological Engineering
Communities and technologies
Journal of Biomedical Informatics - Special issue: Unified medical language system
Artificial Intelligence in Medicine
Towards the design of intelligent CAD systems: An ontological approach
Advanced Engineering Informatics
Extracting Relevant Attribute Values for Improved Search
IEEE Internet Computing
On Ontology, ontologies, Conceptualizations, Modeling Languages, and (Meta)Models
Proceedings of the 2007 conference on Databases and Information Systems IV: Selected Papers from the Seventh International Baltic Conference DB&IS'2006
From web directories to ontologies: natural language processing challenges
ISWC'07/ASWC'07 Proceedings of the 6th international The semantic web and 2nd Asian conference on Asian semantic web conference
Hi-index | 0.00 |
In this paper, we discuss the challenges posed by the NEUROWEB project, as a case study of ontological modeling at a knowledge interface between neurovascular medicine and genomics. The aim of the project is the development of a support system for association studies. We identify the notion of clinical phenotypes, that is, the pathological condition of a patient, as the central construct of the knowledge model. Clinical phenotypes are assessed through the diagnostic activity, performed by clinical experts operating within communities of practice; the different communities operate according to specific procedures, but they also conform to the minimal requirements of international guidelines, displayed by the adoption of a common standard for the patient classification. We develop a central model for the clinical phenotypes, able to reconcile the different methodologies into a common classificatory system. To bridge neurovascular medicine and genomics, we identify the general theory of biological function as the common ground between the two disciplines; therefore, we decompose the clinical phenotypes into elementary phenotypes with a homogeneous physiological background, and we connect them to the biological processes, acting as the elementary units of the genomic world.