Stochastic modelling of insulin sensitivity and adaptive glycemic control for critical care
Computer Methods and Programs in Biomedicine
Monte Carlo analysis of a new model-based method for insulin sensitivity testing
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
Modelling acute renal failure using blood and breath biomarkers in rats
Computer Methods and Programs in Biomedicine
Independent cohort cross-validation of the real-time DISTq estimation of insulin sensitivity
Computer Methods and Programs in Biomedicine
Development of a model-based clinical sepsis biomarker for critically ill patients
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
Development of blood glucose control for extremely premature infants
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
Modeling the glucose regulatory system in extreme preterm infants
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
Mathematical modelling and parameter estimation of the Serra da Mesa basin
Mathematical and Computer Modelling: An International Journal
First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients
Computer Methods and Programs in Biomedicine
Adaptive blood glucose control for intensive care applications
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
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Hyperglycaemia in critically ill patients increases the risk of further complications and mortality. This paper introduces a model capable of capturing the essential glucose and insulin kinetics in patients from retrospective data gathered in an intensive care unit (ICU). The model uses two time-varying patient specific parameters for glucose effectiveness and insulin sensitivity. The model is mathematically reformulated in terms of integrals to enable a novel method for identification of patient specific parameters. The method was tested on long-term blood glucose recordings from 17 ICU patients, producing 4% average error, which is within the sensor error. One-hour forward predictions of blood glucose data proved acceptable with an error of 2-11%. All identified parameter values were within reported physiological ranges. The parameter identification method is more accurate and significantly faster computationally than commonly used non-linear, non-convex methods. These results verify the model's ability to capture long-term observed glucose-insulin dynamics in hyperglycemic ICU patients, as well as the fitting method developed. Applications of the model and parameter identification method for automated control of blood glucose and medical decision support are discussed.