Statistical analysis of neuromuscular blockade response: contributions to an automatic controller calibration

  • Authors:

  • M. Eduarda Silva;Teresa Mendonça;Isabel Silva;Hugo Magalhães

  • Affiliations:

  • Departamento de Matemática Aplicada, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal and UI&D Matemáática e Aplicaçíes ...;Departamento de Matemática Aplicada, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal and UI&D Matemáática e Aplicaçíes ...;Departamento de Matemática Aplicada, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal and Departamento de Engenharia Civil, Faculdade de En ...;Departamento de Matemática Aplicada, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal and UI&D Matemáática e Aplicaçíes ...

  • Venue:
  • Computational Statistics & Data Analysis
  • Year:
  • 2005

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Abstract

Muscle relaxant drugs are currently given during surgical operations. The design of controllers for the automatic control of neuromuscular blockade benefits from an individual tuning of the controller to the characteristics of the patient. A novel approach to the characterization of the neuromuscular blockade response induced by an initial bolus at the beginning of anaesthesia is proposed. This approach is based on the statistical analysis of the data using principal components and Walsh-Fourier spectral analysis. These methods provide information about the patients dynamics, allowing the on-line autocalibration of the controller, using multiple linear regression techniques. Observed and simulated data are used to compare different approaches to the characterization of the bolus response.