Instance-Based Learning Algorithms
Machine Learning
Elements of information theory
Elements of information theory
Machine Learning
On Changing Continuous Attributes into Ordered Discrete Attributes
EWSL '91 Proceedings of the European Working Session on Machine Learning
Inference for the Generalization Error
Machine Learning
Data Mining: Practical Machine Learning Tools and Techniques, Second Edition (Morgan Kaufmann Series in Data Management Systems)
Estimating continuous distributions in Bayesian classifiers
UAI'95 Proceedings of the Eleventh conference on Uncertainty in artificial intelligence
Filter versus wrapper gene selection approaches in DNA microarray domains
Artificial Intelligence in Medicine
Ensemble transcript interaction networks: A case study on Alzheimer's disease
Computer Methods and Programs in Biomedicine
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Microarray-based global gene expression profiling, with the use of sophisticated statistical algorithms is providing new insights into the pathogenesis of autoimmune diseases. We have applied a novel statistical technique for gene selection based on machine learning approaches to analyze microarray expression data gathered from patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS), two autoimmune diseases of unknown genetic origin that share many common features. The methodology included a combination of three data discretization policies, a consensus gene selection method, and a multivariate correlation measurement. A set of 150 genes was found to discriminate SLE and PAPS patients from healthy individuals. Statistical validations demonstrate the relevance of this gene set from an univariate and multivariate perspective. Moreover, functional characterization of these genes identified an interferon-regulated gene signature, consistent with previous reports. It also revealed the existence of other regulatory pathways, including those regulated by PTEN, TNF, and BCL-2, which are altered in SLE and PAPS. Remarkably, a significant number of these genes carry E2F binding motifs in their promoters, projecting a role for E2F in the regulation of autoimmunity.