Machine learning and genetic algorithms in pharmaceutical development and manufacturing processes

  • Authors:
  • Hoi-Ming Chi;Herbert Moskowitz;Okan K. Ersoy;Kemal Altinkemer;Peter F. Gavin;Bret E. Huff;Bernard A. Olsen

  • Affiliations:
  • The Krannert School of Management, Purdue University, 403 West State Street, West Lafayette IN 47907-2056, United States and School of Electrical and Computer Engineering, Purdue University, West ...;The Krannert School of Management, Purdue University, 403 West State Street, West Lafayette IN 47907-2056, United States;School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907-2035, United States;The Krannert School of Management, Purdue University, 403 West State Street, West Lafayette IN 47907-2056, United States;Eli Lilly and Company, 1650 Lilly Road, Lafayette, Indiana, 47905, United States;Eli Lilly and Company, 1650 Lilly Road, Lafayette, Indiana, 47905, United States;Eli Lilly and Company, 1650 Lilly Road, Lafayette, Indiana, 47905, United States

  • Venue:
  • Decision Support Systems
  • Year:
  • 2009

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Abstract

We develop an adaptive Automated Intelligent Manufacturing System (AIMS) for Case 1:to a well-understood-pharmaceutical-process to demonstrate our methodology, Case 2:with clustering, to a not-well-controlled or understood-process for seemingly identical experiments yielding disparate results, Case 3:to scale-up a process from development to manufacturing, and Case 4:to deploy AIMS adaptively, to modify the process model and reoptimize the system contemporaneously, when predictive errors are significant. The results showed AIMS had both explanatory and predictive power. We have developed the following methodological extensions: a random probe method for feature selection, a simulation approach to establish tolerances for target inputs, and an adaptive capability integrated with statistical-process-control to modify the model.