Automatic determination of amino acid sequences

  • Authors:

  • S. A. Bernhard;D. F. Bradley;W. L. Duda

  • Affiliations:

  • Institute of Molecular Biology, University of Oregon, Eugene, Oregon;Chaim Weitzmann Institute of Science, Rehovot, Israel and National Institute of Mental Health, Bethesda, Maryland;-

  • Venue:
  • IBM Journal of Research and Development
  • Year:
  • 1963

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Abstract

A fundamental problem for biochemistry is the determination of the linear sequence of amino acids in proteins. This paper describes a computer-oriented logic for obtaining such determination. The logic applies successively stronger decision rules to extract the required information on the protein sequence.