Changes in quadratic phase coupling of EEG signals during wake and sleep in two chronic insomnia patients, before and after cognitive behavioral therapy

Authors:
Stephen Perrig;Pierre Dutoit;Katerina Espa-Cervena;Vladislav Shaposhnyk;Laurent Pelletier;François Berger;Alessandro E. P. Villa
Affiliations:
Sleep Laboratory, Neuropsychiatry Service Belle-Idée, Hôpitaux Universitaires de Genève, Switzerland;Neuroheuristic Research Group, Grenoble Institute of Neuroscience, Université Joseph Fourier, Grenoble, France;Sleep Laboratory, Neuropsychiatry Service Belle-Idée, Hôpitaux Universitaires de Genève, Switzerland;Neuroheuristic Research Group, Grenoble Institute of Neuroscience, Université Joseph Fourier, Grenoble, France;Neuroheuristic Research Group, Grenoble Institute of Neuroscience, Université Joseph Fourier, Grenoble, France;Neuroheuristic Research Group, Grenoble Institute of Neuroscience, Université Joseph Fourier, Grenoble, France;Sleep Laboratory, Neuropsychiatry Service Belle-Idée, Hôpitaux Universitaires de Genève, Switzerland and Neuroheuristic Research Group, Grenoble Institute of Neuroscience, Universit ...
Venue:
Proceedings of the 2009 conference on Neural Nets WIRN09: Proceedings of the 19th Italian Workshop on Neural Nets, Vietri sul Mare, Salerno, Italy, May 28--30 2009
Year:
2009

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Abstract

Quantitative EEG studies of primary insomnia (PI) suggest that increased high frequency and reduction in slow frequency EEG activity could be associated with cortical “hyperarousal” and sleep homeostasis dysregulation. This preliminary study is the first to apply higher order EEG analysis in chronic PI patients. We analyzed phase coupling in two patients against two control subjects. We defined an index of resonant frequency (IRF) and show that both patients were characterized by high IRF values that suggest an increase in local cortical information processing before treatment. We show that cognitive behavioral therapy for insomnia (CBT-T) is able to reverse EEG phase coupling towards control values in as little as eight sessions. After treatment the patients were characterized by lower index values, thus suggesting recovery of information processing over wide-spread cortical areas.