Joint brain parametric T1-map segmentation and RF inhomogeneity calibration

Authors:
Ping-Feng Chen;R. Grant Steen;Anthony Yezzi;Hamid Krim
Affiliations:
Department of Electrical and Computer Engineering, North Carolina State University, NC;Medical Communications Consultants, Chapel Hill, NC;School of Electrical and Computer Engineering, Georgia Institute of Technology, GA;Department of Electrical and Computer Engineering, North Carolina State University, NC
Venue:
Journal of Biomedical Imaging
Year:
2009

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Abstract

We propose a constrained version of Mumford and Shah's (1989) segmentation model with an information-theoretic point of view in order to devise a systematic procedure to segment brain magnetic resonance imaging (MRI) data for parametric T1-Map and T1-weighted images, in both 2-D and 3D settings. Incorporation of a tuning weight in particular adds a probabilistic flavor to our segmentation method, and makes the 3-tissue segmentation possible. Moreover, we proposed a novel method to jointly segment the T1-Map and calibrate RF Inhomogeneity (JSRIC). This method assumes the average T1 value of white matter is the same across transverse slices in the central brain region, and JSRIC is able to rectify the flip angles to generate calibrated T1-Maps. In order to generate an accurate T1-Map, the determination of optimal flip-angles and the registration of flip-angle images are examined. Our JSRIC method is validated on two human subjects in the 2D T1-Map modality and our segmentation method is validated by two public databases, BrainWeb and IBSR, of T1-weighted modality in the 3D setting.