Computer simulation of the influence of cellular adhesion on the morphology of the interface between tissues of proliferating and quiescent cells

Authors:
Marcos A. Knewitz;José C. M. Mombach
Affiliations:
Laboratório de Bioinformática e Biologia Computacional, Centro de Ciências Exatas e Tecnológicas, Universidade doVale do Rio dos Sinos, 93022-000 São Leopoldo, RS, Brazil;Laboratório de Bioinformática e Biologia Computacional, Centro de Ciências Exatas e Tecnológicas, Universidade doVale do Rio dos Sinos, 93022-000 São Leopoldo, RS, Brazil
Venue:
Computers in Biology and Medicine
Year:
2006

Citing 2
Cited 0

CompuCell, a multi-model framework for simulation of morphogenesis

Bioinformatics
Stochastic simulation of benign avascular tumour growth using the Potts model

Mathematical and Computer Modelling: An International Journal

Quantified Score

Hi-index	0.00

Visualization

Abstract

We investigate the influence of cellular adhesion on the morphology of the interface between a tissue of proliferating and quiescent cells using the cellular Potts model. We show that a decrease in surface tension changes the morphology of the interface and that only for negative surface tensions cell detachment from the proliferative tissue occurs suggesting that this might be a necessary condition for metastatization in malignant neoplasies.