Goal driven analysis of cDNA microarray data

Authors:
Youlian Pan;Jitao Zou;Yi Huang;Ziying Liu;Sieu Phan;Fazel A. Famili
Affiliations:
Institute for Information Technology, NRC, Ottawa, ON, Canada;Plant Biotechnology Institute, NRC, Saskatoon, SK, Canada;Plant Biotechnology Institute, NRC, Saskatoon, SK, Canada;Institute for Information Technology, NRC, Ottawa, ON, Canada;Institute for Information Technology, NRC, Ottawa, ON, Canada;Institute for Information Technology, NRC, Ottawa, ON, Canada
Venue:
CIBCB'09 Proceedings of the 6th Annual IEEE conference on Computational Intelligence in Bioinformatics and Computational Biology
Year:
2009

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Abstract

Microarray technology has been used extensively for high throughput gene expression studies. Many bioinformatics tools are available for analysis of microarray data. In the data mining process, it is important to be goal oriented so that a set of proper tools can be assembled for the targeted knowledge discovery process. In this paper, we tackle this issue by using a microarray dataset from Brassica endosperm together with EST data to validate our process. We were most interested in which genes are highly expressed in Brassica endosperm and their variations and functions over various stages in embryo development. We also performed gene characterization based on gene ontology analysis. Our results indicate that designing a specific data mining workflow that considers both the log ratio and signal intensity enhances knowledge discovery process. Through this approach, we were able to find the regulatory relationship between two most important transcription factors, LEC1 and WRI1 in the endosperm of Brassica napus.