Supervised Nonparametric Image Parcellation

  • Authors:
  • Mert R. Sabuncu;B. T. Yeo;Koen Leemput;Bruce Fischl;Polina Golland

  • Affiliations:
  • Computer Science and Artificial Intelligence Lab, MIT,;Computer Science and Artificial Intelligence Lab, MIT,;Computer Science and Artificial Intelligence Lab, MIT, and Department of Radiology, Harvard Medical School, and Dept. of Information and Computer Science, Helsinki University of Technology,;Computer Science and Artificial Intelligence Lab, MIT, and Department of Radiology, Harvard Medical School,;Computer Science and Artificial Intelligence Lab, MIT,

  • Venue:
  • MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part II
  • Year:
  • 2009

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Abstract

Segmentation of medical images is commonly formulated as a supervised learning problem, where manually labeled training data are summarized using a parametric atlas. Summarizing the data alleviates the computational burden at the expense of possibly losing valuable information on inter-subject variability. This paper presents a novel framework for Supervised Nonparametric Image Parcellation (SNIP). SNIP models the intensity and label images as samples of a joint distribution estimated from the training data in a non-parametric fashion. By capitalizing on recently developed fast and robust pairwise image alignment tools, SNIP employs the entire training data to segment a new image via Expectation Maximization. The use of multiple registrations increases robustness to occasional registration failures. We report experiments on 39 volumetric brain MRI scans with manual labels for the white matter, cortex and subcortical structures. SNIP yields better segmentation than state-of-the-art algorithms in multiple regions of interest.