Patient Specific 4D Coronary Models from ECG-gated CTA Data for Intra-operative Dynamic Alignment of CTA with X-ray Images

Authors:
Coert T. Metz;Michiel Schaap;Stefan Klein;Lisan A. Neefjes;Ermanno Capuano;Carl Schultz;Robert Jan Geuns;Patrick W. Serruys;Theo Walsum;Wiro J. Niessen
Affiliations:
Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Radiology and Cardiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Radiology and Cardiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Radiology and Cardiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Radiology and Cardiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Cardiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands;Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands and Faculty of Applied Sciences, Delft University of Technology, The Netherlands
Venue:
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part I
Year:
2009

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Abstract

We present an approach to derive patient specific coronary models from ECG-gated CTA data and their application for the alignment of CTA with mono-plane X-ray imaging during interventional cardiology. A 4D (3D+t) deformation model of the coronary arteries is derived by (i) extraction of a 3D coronary model at an appropriate cardiac phase and (ii) non-rigid registration of the CTA images at different ECG phases to obtain a deformation model. The resulting 4D coronary model is aligned with the X-ray data using a novel 2D+t/3D+t registration approach. Model consistency and accuracy is evaluated using manually annotated coronary centerlines at systole and diastole as reference. Improvement of registration robustness by using the 2D+t/3D+t registration is successfully demonstrated by comparison of the actual X-ray cardiac phase with the automatically determined best matching phase in the 4D coronary model.