Denoising Intra-voxel Axon Fiber Orientations by Means of ECQMMF Method

  • Authors:
  • Alonso Ramirez-Manzanares;Mariano Rivera;James C. Gee

  • Affiliations:
  • Facultad de Matematicas, Valenciana, Universidad de Guanajuato, Guanajuato, Gto., Mexico C.P. 36000;CIMAT A.C., Guanajuato, Gto, Mexico C.P. 36000;PICSL, Department of Radiology, University of Pennsylvania, USA 19104

  • Venue:
  • MICAI '09 Proceedings of the 8th Mexican International Conference on Artificial Intelligence
  • Year:
  • 2009

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Abstract

Diffusion weighted magnetic resonance imaging is widely used in the study of the structure of the fiber pathways in brain white matter. In this work we present a new method for denoising intra---voxel axon fiber tracks. In order to improve local (voxelwise) estimations, we use the general---purpose segmentation method called Entropy---Controlled Quadratic Markov Measure Field Models. Our proposal is capable of spatially---regularize multiple axon fiber orientations (intra-voxel orientations). In order to provide the best as possible local axon orientations to our spatial regularization procedure, we evaluate two optimization methods for fitting a Diffusion Basis Function model. We present qualitative results on real human Diffusion Weighted MRI data where the ground---truth is not available, and we quantitatively validate our results by synthetic experiments.