Renewable, Time-Responsive DNA Logic Gates for Scalable Digital Circuits

Authors:
Ashish Goel;Morteza Ibrahimi
Affiliations:
Departments of Management Science and Engineering, and by courtesy, Computer Science, Stanford University,;Departments of Electrical Engineering, Stanford University,
Venue:
DNA Computing and Molecular Programming
Year:
2009

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Scalable, time-responsive, digital, energy-efficient molecular circuits using DNA strand displacement

DNA'10 Proceedings of the 16th international conference on DNA computing and molecular programming
Computational biology: a programming perspective

Formal modeling

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Abstract

In this article, we introduce a design of DNA logic gates based on enzymatic restriction of DNA strands. We present a construction for a set of one and two-input logic gates and argue that our construction can be generalized to implement any Boolean operation. A key feature of our design is its time-responsiveness, in the presence of appropriate fuels these gates can operate continuously and generate a time-dependent output in response to a time-dependant input. They can be interconnected to form digital circuits. Moreover, modulo connectivity information, the strand design and circuit design phases are decoupled.