Local Kernel for Brains Classification in Schizophrenia

  • Authors:
  • U. Castellani;E. Rossato;V. Murino;M. Bellani;G. Rambaldelli;M. Tansella;P. Brambilla

  • Affiliations:
  • VIPS lab, University of Verona, Italy;VIPS lab, University of Verona, Italy;VIPS lab, University of Verona, Italy;Department of Medicine and Public Health, University of Verona, Italy;Department of Medicine and Public Health, University of Verona, Italy;Department of Medicine and Public Health, University of Verona, Italy;Department of Medicine and Public Health, University of Verona, Italy and ICBN Center, University of Udine and Verona, Italy

  • Venue:
  • AI*IA '09: Proceedings of the XIth International Conference of the Italian Association for Artificial Intelligence Reggio Emilia on Emergent Perspectives in Artificial Intelligence
  • Year:
  • 2009

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Abstract

In this paper a novel framework for brain classification is proposed in the context of mental health research. A learning by example method is introduced by combining local measurements with non linear Support Vector Machine. Instead of considering a voxel-by-voxel comparison between patients and controls, we focus on landmark points which are characterized by local region descriptors, namely Scale Invariance Feature Transform (SIFT). Then, matching is obtained by introducing the local kernel for which the samples are represented by unordered set of features. Moreover, a new weighting approach is proposed to take into account the discriminative relevance of the detected groups of features. Experiments have been performed including a set of 54 patients with schizophrenia and 54 normal controls on which region of interest (ROI) have been manually traced by experts. Preliminary results on Dorso-lateral PreFrontal Cortex (DLPFC) region are promising since up to 75% of successful classification rate has been obtained with this technique and the performance has improved up to 85% when the subjects have been stratified by sex.