ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
MIAR'10 Proceedings of the 5th international conference on Medical imaging and augmented reality
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A novel method for the segmentation of brain structures combining registration-based and EM-based approaches is proposed. To address the issue of intensity variation within brain structures, we propose a method for creating spatial prior corresponding very well with the new subject anatomy, referred to as subject-specific atlas. The subject-specific atlas is created using multiple non-rigid registrations with the new subject, and therefore a robust non-rigid alignment of the prior with the image is achieved. The final EM segmentation step ensures a good quality classification of the complicated cortical structures based on intensity. The evaluation of the proposed method shows consistent results superior to both, registration-based and EM-based approaches.