Micro-CT examinations of trabecular bone samples at different resolutions: 14,7 and 2 micron level
Technology and Health Care - Special issue on bone architecture and the competence of bone
Muliscale Vessel Enhancement Filtering
MICCAI '98 Proceedings of the First International Conference on Medical Image Computing and Computer-Assisted Intervention
CVRMed-MRCAS '97 Proceedings of the First Joint Conference on Computer Vision, Virtual Reality and Robotics in Medicine and Medial Robotics and Computer-Assisted Surgery
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The investigation of cellular aspects of bone tissue is generally performed from 2D microscopic techniques. Recent advances in Synchrotron Radiation Micro-CT allow to image biological samples at a sub-micrometric scale. In this paper, we propose to study the feasibility of this technique to study the bone lacuno-canalicular system, consisting in a complex network of thin canaliculi (diameter ∼ 500 nm) joining osteocytes. Due to the limited spatial resolution of the imaging system compared to the structure size and the constraints in term of dose, the images have a low signal to noise ratio and the detection of canaliculi is challenging. We propose a 3D non-linear enhancement technique based on Hessian analysis. The method is first evaluated on synthetic images, then we show, for the first time, a 3D rendering of the canalicular network based on experimental data.