Anatomical variability of organs via principal factor analysis from the construction of an abdominal probabilistic atlas

Authors:
Mauricio Reyes;Miguel A. Gonzalez Ballester;Zhixi Li;Nina Kozic;See Chin;Ronald M. Summers;Marius George Linguraru
Affiliations:
ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland;Alma IT Systems, Barcelona, Spain;Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD;ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland;Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD;Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD;Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD
Venue:
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Year:
2009

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Abstract

Extensive recent work has taken place on the construction of probabilistic atlases of anatomical organ. We propose a probabilistic atlas of ten major abdominal organs which retains structural variability by using a size-preserving affine registration, and normalizes the physical organ locations to an anatomical landmark. Restricting the degrees of freedom in the transformation, the bias from the reference data is minimized, in terms of organ shape, size and position. Additionally, we present a scheme for the study of anatomical variability within the abdomen, including the clusterization of the modes of variation. The analysis of deformation fields showed a strong correlation with anatomical landmarks and known mechanical deformations in the abdomen. The atlas and its dependencies represent a potentially important research tool for abdominal diagnosis, modeling and soft tissue interventions.