MRI-ultrasound registration for targeted prostate biopsy

Authors:
R. Narayanan;J. Kurhanewicz;K. Shinohara;E. D. Crawford;A. Simoneau;J. S. Suri
Affiliations:
Eigen LLC, Grass Valley, CA;University of California, San Francisco, CA;University of California, San Francisco, CA;University of Colorado, Denver, CO;University of California, Irvine, CA;Eigen LLC, Grass Valley, CA
Venue:
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Year:
2009

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Abstract

T2-weighted magnetic resonance images (MRI) imaging using an endorectal coil combined with a pelvic phased-array coil has been shown to provide high resolution images of the prostate. To integrate MRI analysis in standard prostate biopsy procedures, preoperative MRI must be accurately registered to 3-D transrectal ultrasound (TRUS) images. Shape changes due to patient motion, or drugs can induce further differences in glandular shape variation between preoperative MRI and 3-D TRUS during biopsy. In the proposed work, we model the deformation relating MRI and TRUS so as to enable analysis of MRI in conjunction with ultrasound (color blended or side-by-side) for planning of biopsy targets. Registration of MRI at various resolutions and endorectal balloon volumes and ultrasound volumes yielded average fiducial registration error of 3.06 mm using 6 and 12 bead phantoms.