Fully integrated CMOS nano-particle assembly circuit for biological detections

  • Authors:

  • Lei Zhang;Yu Chang;Zhiping Yu;Xiangqing He;Yong Chen

  • Affiliations:

  • Institute of Microelectronics, Tsinghua University, Beijing, People's Republic of China 100084;Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA 90095;Institute of Microelectronics, Tsinghua University, Beijing, People's Republic of China 100084;Institute of Microelectronics, Tsinghua University, Beijing, People's Republic of China 100084;Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA 90095

  • Venue:
  • Analog Integrated Circuits and Signal Processing
  • Year:
  • 2010

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Abstract

Recently, along with the booming of research and production of CMOS Integrated Bio-sensing System, selective assembly of organic nano-particles on the on-chip electrodes, which serves for specific bio-sensing and detection purposes, is in high demand in areas like biological analysis and detection, DNA probing and surveying systems and etc. In this paper, a fully integrated bio-circuit targeting at electrical selective assembly of charged nano-particles is proposed and designed in SMIC 0.18 μm CMOS mixed signal process. The proposed circuit integrates the 16 pixels of 19 μm 脳 19 μm electrode array, counter electrode, potentiostat circuit, digital decoding circuit, as well as control logics on a single chip, and provides a rail-to-rail range of assembling voltage, a potential resolution of 8 bit, and a maximal assembling current up to 459 μA, biased at a current of 1 μA. Meanwhile, a novel electrode-reuse scheme is also proposed to further simplify the architecture and save chip area as well, without degrading the functionalities. Experimental results from on-chip selective assembly of 50 nm polystyrene nano-particles are included and discussed to verify the feasibility of the proposed circuits.