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This paper presents a novel Human-Computer Interaction in smart home healthcare, which is an interdisciplinary research project between computer science, social work and psychology, an integration of human, smart home environment and healthcare services is connected with the intelligent interface, which processes sensory modalities input via facial, vocal, eye-tracking, and physiological signals, recognizing both the user’s healthy state and emotional state, building the emotion model based on Artificial Psychology theory, we propose the system can be accepted into the smart home environment to improve the healthcare interaction quality.