Letters: A reliable method for HIV-1 protease cleavage site prediction

  • Authors:
  • Loris Nanni;Alessandra Lumini

  • Affiliations:
  • DEIS, IEIIT-CNR, Universití di Bologna, Viale Risorgimento 2, 40136 Bologna, Italy;DEIS, IEIIT-CNR, Universití di Bologna, Viale Risorgimento 2, 40136 Bologna, Italy

  • Venue:
  • Neurocomputing
  • Year:
  • 2006

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Abstract

Recently, several works have approached the HIV-1 protease specificity problem by applying techniques from machine learning. In this work, an encoding scheme based on the BLOSUM50 matrix is investigated. We show that combining a linear discriminant classifier and radial basis function support vector machine we obtain performance higher than previously published in the literature.