Deficiencies in traditional measures of in vitro hippocampal rhythms

  • Authors:

  • J. A. Gillis;L. Zhang;F. K. Skinner

  • Affiliations:

  • Toronto Western Research Institute, UHN, Toronto, ON, Canada and Physiol. (Neurol.), University of Toronto, Toronto, ON, Canada;Toronto Western Research Institute, UHN, Toronto, ON, Canada and Med. (Neurol.), University of Toronto, Toronto, ON, Canada;Toronto Western Research Institute, UHN, Toronto, ON, Canada and Physiol. (Neurol.), University of Toronto, Toronto, ON, Canada and Med. (Neurol.), University of Toronto, Toronto, ON, Canada and I ...

  • Venue:
  • Neurocomputing
  • Year:
  • 2006

Quantified Score

Hi-index 0.01

Visualization

Abstract

An in vitro thick slice mouse hippocampus preparation exhibits spontaneous rhythmic local field potentials in the 3-4Hz range due to synchronous discharges in the inhibitory interneuron population. Intracellular rhythms are recorded concurrently with field rhythms from this preparation in data sets of approximately 3min durations. Cross-correlation, phase and frequency distribution are used to compare intracellular and field rhythms and generate groups of activity in the time-frequency domain. We find that patterns of activity present in time-frequency are obscured using other techniques and we characterize the activity that is omitted.