Noise-based feature perturbation as a selection method for microarray data

Authors:
Li Chen;Dmitry B. Goldgof;Lawrence O. Hall;Steven A. Eschrich
Affiliations:
Department of Computer Science and Engineering, University of South Florida;Department of Computer Science and Engineering, University of South Florida;Department of Computer Science and Engineering, University of South Florida;Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Cancer & Research Institute, Univeristy of South Florida, Tampa, FL
Venue:
ISBRA'07 Proceedings of the 3rd international conference on Bioinformatics research and applications
Year:
2007

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Abstract

DNA microarrays can monitor the expression levels of thousands of genes simultaneously, providing the opportunity for the identification of genes that are differentially expressed across different conditions. Microarray datasets are generally limited to a small number of samples with a large number of gene expressions, therefore feature selection becomes a very important aspect of the microarray classification problem. In this paper, a new feature selection method, feature perturbation by adding noise, is proposed to improve the performance of classification. The experimental results on a benchmark colon cancer dataset indicate that the proposed method can result in more accurate class predictions using a smaller set of features when compared to the SVM-RFE feature selection method.