Intensity modulated beam radiation therapy dose optimization with multiobjective evolutionary algorithms

Authors:
Michael Lahanas;Eduard Schreibmann;Natasa Milickovic;Dimos Baltas
Affiliations:
Department of Medical Physics and Engineering, Strahlenklinik, Klinikum, Offenbach, Germany;Department of Medical Physics and Engineering, Strahlenklinik, Klinikum, Offenbach, Germany and Medical Physics Department, Medical School, Patras University;Department of Medical Physics and Engineering, Strahlenklinik, Klinikum, Offenbach, Germany;Department of Medical Physics and Engineering, Strahlenklinik, Klinikum, Offenbach, Germany and Institute of Communication and Computer Systems, National Technical University of Athens, Zografou, ...
Venue:
EMO'03 Proceedings of the 2nd international conference on Evolutionary multi-criterion optimization
Year:
2003

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Abstract

We apply the NSGA-II algorithm and its controlled elitist version NSGA-IIc for the intensity modulated beam radiotherapy dose optimization problem. We compare the performance of the algorithms with objectives for which deterministic optimization methods provide global optimal solutions. The number of parameters to be optimized can be up to a few thousands and the number of objectives varies from 3 to 6. We compare the results with and without supporting solutions. Optimization with constraints for the target dose variance value provides clinical acceptable solutions.