An introduction to support Vector Machines: and other kernel-based learning methods
An introduction to support Vector Machines: and other kernel-based learning methods
Two-stage support vector machines for protein secondary structure prediction
Neural, Parallel & Scientific Computations - Special issue: Advances in intelligent systems and applications
Data Mining: Practical Machine Learning Tools and Techniques, Second Edition (Morgan Kaufmann Series in Data Management Systems)
Prediction of Protein Secondary Structure with two-stage multi-class SVMs
International Journal of Data Mining and Bioinformatics
A comparison of methods for multiclass support vector machines
IEEE Transactions on Neural Networks
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Knowledge of protein-protein interaction sites is vital to determine proteins' function and involvement in different pathways. Support Vector Machines (SVM) have been proposed over the recent years to predict protein-protein interface residues, primarily based on single amino acid sequence inputs. We investigate the features of amino acids that can be best used with SVM for predicting residues at proteinprotein interfaces. The optimal feature set was derived from investigation into features such as amino acid composition, hydrophobic characters of amino acids, secondary structure propensity of amino acids, accessible surface areas, and evolutionary information generated by PSI-BLAST profiles. Using a backward elimination procedure, amino acid composition, accessible surface areas, and evolutionary information generated by PSI-BLAST profiles gave the best performance. The present approach achieved overall prediction accuracy of 74.2% for 77 individulal proteins collected from the Protein Data Bank, which is better than the previously reported accuracies.