IEEE Computer Graphics and Applications
Neuroinformatics for Genome-Wide 3-D Gene Expression Mapping in the Mouse Brain
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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The Allen Brain Atlas (ABA), publicly available at http:// www.brain-map.org, presents the expression patterns of more than 21,500 genes in the adult mouse brain. The project has produced more than 600 Terabytes of cellular level in situ hybridization data whose images have been reconstructed and mapped into whole brain 3D volumes for search and viewing. In this application paper we outline the bioinformatics, data integration, and presentation approach to the ABA and the creation a fully automated high-throughput pipeline to deliver this data set to the Web.