Toward an integrated RNA motif database

  • Authors:
  • Jason T. L. Wang;Dongrong Wen;Bruce A. Shapiro;Katherine G. Herbert;Jing Li;Kaushik Ghosh

  • Affiliations:
  • Bioinformatics Program and Department of Computer Science, New Jersey Institute of Technology, Newark, NJ;Bioinformatics Program and Department of Computer Science, New Jersey Institute of Technology, Newark, NJ;Center for Cancer Research Nanobiology Program, National Cancer Institute, Frederick, MD;Department of Computer Science, Montclair State University, Montclair, NJ;Applied Statistics Program and Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ;Applied Statistics Program and Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ

  • Venue:
  • DILS'07 Proceedings of the 4th international conference on Data integration in the life sciences
  • Year:
  • 2007

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Abstract

In this paper we present the design and implementation of an RNA structural motif database, called RmotifDB. The structural motifs stored in RmotifDB come from three sources: (1) collected manually from biomedical literature; (2) submitted by scientists around the world; and (3) discovered by a wide variety of motif mining methods. We present here a motif mining method in detail. We also describe the interface and search mechanisms provided by RmotifDB as well as techniques used to integrate RmotifDB with the Gene Ontology. The RmotifDB system is fully operational and accessible on the Internet at http://datalab.njit.edu/bioinfo/