High level group analysis of FMRI data based on dirichlet process mixture models

  • Authors:
  • Bertrand Thirion;Alan Tucholka;Merlin Keller;Philippe Pinel;Alexis Roche;Jean-François Mangin;Jean-Baptiste Poline

  • Affiliations:
  • INRIA Futurs, Neurospin, Gif-sur-Yvette cedex, France;CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette cedex, France;INRIA Futurs, Neurospin, Gif-sur-Yvette cedex, France;Unité INSERM, Gif-sur-Yvette cedex, France;CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette cedex, France;CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette cedex, France;CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette cedex, France

  • Venue:
  • IPMI'07 Proceedings of the 20th international conference on Information processing in medical imaging
  • Year:
  • 2007

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Abstract

Inferring the position of functionally active regions from a multi-subject fMRI dataset involves the comparison of the individual data and the inference of a common activity model. While voxel-based analyzes, e.g. Random Effect statistics, are widely used, they do not model each individual activation pattern. Here, we develop a new procedure that extracts structures individually and compares them at the group level. For inference about spatial locations of interest, a Dirichlet Process Mixture Model is used. Finally, inter-subject correspondences are computed with Bayesian Network models. We show the power of the technique on both simulated and real datasets and compare it with standard inference techniques.