Ten lectures on wavelets
Segmentation of complementary DNA microarray images by wavelet-based Markov random field model
IEEE Transactions on Information Technology in Biomedicine - Special section on body sensor networks
A wavelet-based Markov random field segmentation model in segmenting microarray experiments
Computer Methods and Programs in Biomedicine
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In the present study, a new gridding method based on continuous wavelet transform (CWT) was performed. Line profiles of x and y axis were calculated, resulting to 2 different signals. These signals were independently processed by means of CWT at 15 different levels, using daubechies 4 mother wavelet. A summation, point by point, was performed on the processed signals, in order to suppress noise and enhance spot's differences. Additionally, a wavelet based hard thresholding filter was applied to each signal for the task of alleviating the noise of the signals. 14 real microarray images were used in order to visually assess the performance of our gridding method. Each microarray image contained 4 sub-arrays, each sub-array 40x40 spots, thus, 6400 spots totally. Moreover, these images contained contamination areas. According to our results, the accuracy of our algorithm was 98% in all 14 images and in all spots. Additionally, processing time was less than 3 sec on a 1024×1024×16 microarray image, rendering the method a promising technique for an efficient and fully automatic gridding processing.