A multiphysics simulation of a healthy and a diseased abdominal aorta

Authors:
Robert H. P. McGregor;Dominik Szczerba;Gábor Székely
Affiliations:
Computer Vision Laboratory, Zürich, Switzerland;Computer Vision Laboratory, Zürich, Switzerland;Computer Vision Laboratory, Zürich, Switzerland
Venue:
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention
Year:
2007

Citing 1
Cited 3

High Quality Surface Mesh Generation for Multi-physics Bio-medical Simulations

ICCS '07 Proceedings of the 7th international conference on Computational Science, Part I: ICCS 2007

Mechanism and Localization of Wall Failure During Abdominal Aortic Aneurysm Formation

ISBMS '08 Proceedings of the 4th international symposium on Biomedical Simulation
Computational hemodynamics in the human aorta: A computational fluid dynamics study of three cases with patient-specific geometries and inflow rates

Technology and Health Care
Fast Implicit Simulation of Oscillatory Flow in Human Abdominal Bifurcation Using a Schur Complement Preconditioner

Euro-Par '09 Proceedings of the 15th International Euro-Par Conference on Parallel Processing

Quantified Score

Hi-index	0.00

Visualization

Abstract

Abdominal Aortic Aneurysm is a potentially life-threatening disease if not treated adequately. Its pathogenesis is complex and multifactorial and is still not fully understood. Many biochemical and biomechanical mechanisms have been identified as playing a role in the formation of aneurysms but it is as yet unclear what triggers the process. We investigated the role of the relevant biomechanical factors, in particular the wall shear stress and the intramural wall stress by simulating fluid structure interaction between the blood flow and the deforming arterial wall in a healthy abdominal aortic bifurcation, the preferred location of the disease. We then extended this study by introducing a hypothetical weakening of the aortic wall. Intramural wall stress was considerably higher and wall shear stress considerably lower in this configuration, supporting the hypothesis that biomechanical aneurysmal growth factors are self-sustaining.