Principal Warps: Thin-Plate Splines and the Decomposition of Deformations
IEEE Transactions on Pattern Analysis and Machine Intelligence
Ultrasound monitoring of tissue ablation via deformation model and shape priors
MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part II
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An image registration-based elastography algorithm is presented for assessing the stiffness of tissue regions inside the prostate for the purpose of detecting tumors. A 3D finite-element model of the prostate is built from ultrasound images and used to simulate the deformation of the prostate induced by a TRUS probe. To reconstruct the stiffness of tissues, their Young's moduli are varied using Powell's method so that the mutual information between a simulated and deformed image volume is maximized. The algorithm was validated using a gelatin prostate phantom embedded with a cylindrical inclusion that simulated a tumor. Results from the phantom study showed that the technique could detect the increased stiffness of the simulated tumor with a reasonable accuracy.