Neural Computation
Sequence disambiguation by functionally divided hippocampal CA3 model
ICONIP'06 Proceedings of the 13 international conference on Neural Information Processing - Volume Part I
Significance for hippocampal memory of context-like information generated in hippocampal CA3c
ICONIP'08 Proceedings of the 15th international conference on Advances in neuro-information processing - Volume Part I
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Many episodes are acquired in the hippocampus. An episode is expressed by a sequence of elements that are perceived in an event. Episodes are associated each other by events that contain information shared among the episodes. Sequences must be recalled individually, even if the sequences are overlapped at some representations. Therefore, sequence disambiguation is an essential function to dissociate overlapped sequences. In this study, we especially focus on the location-dependencies of the STDP effects on synaptic summation and the expression of AMPA receptor. We firstly show that the hippocampal CA3 is divided into two regions in which one region has spatial selectivity and the other has temporal selectivity. Moreover, we confirm that the divided CA3 could generate a code for sequence disambiguation in computer simulations. Consequently, we suggest that the CA3 can be divided into two regions characterized by their selectivity, and the divided CA3 contributes to sequence disambiguation.