A modified dynamic model for shear stress induced ATP release from vascular endothelial cells

  • Authors:

  • Cheng Xiang;Lingling Cao;Kairong Qin;Zhe Xu;Ben M. Chen

  • Affiliations:

  • Department of Electrical and Computer Engineering, National University of Singapore, Singapore;Department of Electrical and Computer Engineering, National University of Singapore, Singapore;Institute of Mechanobiology and Medical Engineering, Shanghai Jiao Tong University, Shanghai and Institute of Biomechanics, Department of Mechanics and Engineering Science, Fudan University, Shang ...;Institute of Biomechanics, Department of Mechanics and Engineering Science, Fudan University, Shanghai;Department of Electrical and Computer Engineering, National University of Singapore, Singapore

  • Venue:
  • LSMS'07 Proceedings of the Life system modeling and simulation 2007 international conference on Bio-Inspired computational intelligence and applications
  • Year:
  • 2007

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Abstract

A modified dynamic model is proposed for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs) in order to incorporate the activation mechanism by time-varying shear stress. The dynamic behavior of ATP concentration at the endothelium-fluid interface by viscous shear flow is investigated via simulation studies. The numerical results demonstrate that the ATP concentration against time at the endothelium-fluid interface predicted by the modified dynamic ATP release model is more consistent with the experimental observations than that predicted by static ATP release model. The different behaviors of ATP concentration predicted by the original dynamic model and the new one are also compared and analyzed.