An intentional kernel function for RNA classification

  • Authors:
  • Hiroshi Sankoh;Koichiro Doi;Akihiro Yamamoto

  • Affiliations:
  • Graduate School of Informatics, Kyoto University, Kyoto, Japan;Graduate School of Informatics, Kyoto University, Kyoto, Japan;Graduate School of Informatics, Kyoto University, Kyoto, Japan

  • Venue:
  • DS'07 Proceedings of the 10th international conference on Discovery science
  • Year:
  • 2007

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Abstract

This paper presents a kernel function class KRNA which is based on the concept of the intentional kernel (Doi et al., 2006) as opposed to that of the convolution kernel (Haussler, 1999). A kernel function in KRNA computes the similarity between two RNA sequences from the viewpoint of secondary structures. As an instance of KRNA, we give the definition and the algorithm of KRNAN which takes a pair of RNA sequences as its inputs, and facilitates Support Vector Machine (SVM) classifying RNA sequences in a higher dimension space. Our experimental results show a high performance of KRNAN, compared with the string kernel which is a convolution kernel.