A formal and integrated framework to simulate evolution of biological pathways

  • Authors:

  • Lorenzo Dematté;Corrado Priami;Alessandro Romanel;Orkun Soyer

  • Affiliations:

  • The Microsoft Research, University of Trento Centre for Computational and Systems Biology and Dipartimento di Informatica e Telecomunicazioni, Università di Trento;The Microsoft Research, University of Trento Centre for Computational and Systems Biology and Dipartimento di Informatica e Telecomunicazioni, Università di Trento;The Microsoft Research, University of Trento Centre for Computational and Systems Biology and Dipartimento di Informatica e Telecomunicazioni, Università di Trento;The Microsoft Research, University of Trento Centre for Computational and Systems Biology

  • Venue:
  • CMSB'07 Proceedings of the 2007 international conference on Computational methods in systems biology
  • Year:
  • 2007

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Abstract

This paper presents a formal approach to the study of evolution of biological pathways. The basic idea is to use the Beta Workbench to model and simulate pathway in connection with evolutionary algorithms to implement mutations. A fitness function is used to select individuals at any generation. The feasibility of the approach is demonstrated with a simple example.