Shape analysis of human brain with cognitive disorders

Authors:
Tianzi Jiang;Feng Shi;Wanlin Zhu;Shuyu Li;Xiaobo Li
Affiliations:
Institute of Biomedical Informatics, School of Information Science and Engineering, Lanzhou University, Lanzhou, China and National Laboratory of Pattern Recognition, Institute of Automation, Chin ...;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China and Department of Mathematics, Zhejiang University, Hangzhou, China;Department of bioengineering, Beihang University, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Venue:
ICDHM'07 Proceedings of the 1st international conference on Digital human modeling
Year:
2007

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Abstract

In this paper, we present some of our current studies on how human brain structures are influenced by cognitive disorders occurred from various neurological and psychiatric diseases based on magnetic resonance imaging (MRI). We first give a brief introduction about computational neuroanatomy, which is the basis of these studies. In Section 2, several novel methods on segmentations of brain tissue and anatomical substructures were presented. Section 3 presented some studies on brain image registration, which plays a core role in computational neuroanatomy. Shape analysis of substructures, cerebral cortical thickness and complexity was presented in Section 4. Finally, some prospects and future research directions in this field are also given.