Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation

Authors:
Yogender Aggarwal;Bhuwan Mohan Karan;Barda Nand Das;Rakesh Kumar Sinha
Affiliations:
Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India;Department of Electrical & Electronics Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India;Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India;Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India
Venue:
Computers in Biology and Medicine
Year:
2010

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Abstract

The present work is concerned to model the molecular signalling pathway for vasodilation and to predict the resting young human forearm blood flow under heat stress. The mechanistic electronic modelling technique has been designed and implemented using MULTISIM 8.0 and an assumption of 1V/^oC for prediction of forearm blood flow and the digital logic has been used to design the molecular signalling pathway for vasodilation. The minimum forearm blood flow has been observed at 35^oC (0ml100ml^-^1min^-^1) and the maximum at 42^oC (18.7ml100ml^-^1min^-^1) environmental temperature with respect to the base value of 2ml100ml^-^1min^-^1. This model may also enable to identify many therapeutic targets that can be used in the treatment of inflammations and disorders due to heat-related illnesses.