Formal Concept Analysis: Mathematical Foundations
Formal Concept Analysis: Mathematical Foundations
Machine Learning on the Basis of Formal Concept Analysis
Automation and Remote Control
Computing iceberg concept lattices with TITANIC
Data & Knowledge Engineering
Logical analysis of diffuse large B-cell lymphomas
Artificial Intelligence in Medicine
Constructing a Knowledge Base for Gene Regulatory Dynamics by Formal Concept Analysis Methods
AB '08 Proceedings of the 3rd international conference on Algebraic Biology
Two FCA-Based Methods for Mining Gene Expression Data
ICFCA '09 Proceedings of the 7th International Conference on Formal Concept Analysis
Mining gene expression data with pattern structures in formal concept analysis
Information Sciences: an International Journal
Gene expression array exploration using K-formal concept analysis
ICFCA'11 Proceedings of the 9th international conference on Formal concept analysis
Conceptual representation of gene expression processes
KONT'07/KPP'07 Proceedings of the First international conference on Knowledge processing and data analysis
Review: Formal concept analysis in knowledge processing: A survey on applications
Expert Systems with Applications: An International Journal
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When cancer breaks out, central processes in the cell are disturbed. These disturbances are often due to abnormalities in gene expression. The microarray technology allows to monitor the expression of thousands of genes in human cells simultaneously. It is common knowledge that tumor cells show different gene expression profiles compared to normal tissue but also to tissue obtained from metastases. However, the identification of biomarkers, that is sets of genes whose expression change is highly correlated with the disease, poses a great challenge. Increasingly important is the extraction of combinatorial biomarkers. Here, the correlation to the disease is a result of the joint expression of several genes, whereas the single genes do not necessarily distinguish well between healthy and diseased tissue types. In this paper we describe how formal concept analysis can be used to identify gene combinations that are able to distinguish between tumor- and metastasis tissue in breast cancer based on microarray gene expression data.